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Twinrix (Twinrix)
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Common TitleStudy HAB-028: Twinrix and Long-term Persistence after Adult Immunization Industry
Official Title An Open Single Centre Study to Evaluate the Long-term Antibody Persistence and Immune Memory Between 16 and 20 Years After the Primary Study HAB-032 (208127/022) in Which Healthy Adults Were Vaccinated With Twinrix Adult Following a Three-dose Schedule.
Phase Phase IV
ClinicalTrials.gov NCT01037114
Treatments
Twinrix
Twinrix
Tradename:TwinrixClass:Vaccines (HBV)Funding
IndustryGlaxoSmithKline
References
- Van Damme P, Leroux-Roels G, Crasta P, Messier M, Jacquet JM, Van Herck K. Antibody persistence and immune memory in adults, 15 years after a three-dose schedule of a combined hepatitis A and B vaccine. J Med Virol. 2012;84:11-7.
Common TitleStudy 110699: Twinrix and Long-Term after Adolescent Immunization Industry
Official Title An Open Multicentre, Multicountry Study to Evaluate Long-term Antibody Persistence and Immune Memory Between Years 11 and 15 After the Primary Study HAB-084 in Which Healthy Adolescents Were Vaccinated With Twinrix™ Adult Following a Two-dose Schedule or Twinrix™ Junior Following a Three-dose Schedule.
Phase Phase IV
ClinicalTrials.gov NCT00875485
Treatments
Twinrix
Twinrix
Tradename:TwinrixClass:Vaccines (HBV)Funding
IndustryGlaxoSmithKline
References
- Beran J, Kervyn D, Wertzova V, et al. Comparison of long-term (10 years) immunogenicity of two- and three-dose regimens of a combined hepatitis A and B vaccine in adolescents. Vaccine. 2010;28:5993-7.
- Beran J, Van Der Meeren O, Leyssen M, D'silva P. Immunity to hepatitis A and B persists for at least 15 years after immunisation of adolescents with a combined hepatitis A and B vaccine. Vaccine. 2016;34:2686-91.
- Levie K, Beran J, Collard F, Nguyen C. Long term (24 months) follow-up of a hepatitis A and B vaccine, comparing a two and three dose schedule in adolescents aged 12-15 years. Vaccine. 2002;20:2579-84.