All Clinical Trials
Official Title A Randomized, Double-Blind, Controlled Evaluation of Tenofovir DF Versus Adefovir Dipivoxil for the Treatment of Presumed Pre-Core Mutant Chronic Hepatitis B
Phase Phase III
ClinicalTrials.gov NCT00117676
Treatments
Adefovir
, Adefovir
Tradename:HepseraOther Names:ADVClass:Oral Antivirals (Nucleos(t)ide Analogues)Tenofovir DF
Tenofovir DF
Tradename:VireadOther Names:TDF, tenofovir disoproxil fumarateClass:Oral Antivirals (Nucleos(t)ide Analogues)Funding
IndustryGilead Sciences
References
- Marcellin P, Heathcote EJ, Buti M, et al. Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. N Engl J Med. 2008;359:2442-55.
Official Title A Randomized, Double-Blind, Controlled Evaluation of Tenofovir DF Versus Adefovir Dipivoxil for the Treatment of HBeAg Positive Chronic Hepatitis B
Phase Phase III
ClinicalTrials.gov NCT00116805
Treatments
Adefovir
, Adefovir
Tradename:HepseraOther Names:ADVClass:Oral Antivirals (Nucleos(t)ide Analogues)Tenofovir DF
Tenofovir DF
Tradename:VireadOther Names:TDF, tenofovir disoproxil fumarateClass:Oral Antivirals (Nucleos(t)ide Analogues)Funding
IndustryGilead Sciences
References
- Marcellin P, Heathcote EJ, Buti M, et al. Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. N Engl J Med. 2008;359:2442-55.
Official Title Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate for Treatment of Hepatitis B e Antigen-Negative Hepatitis B
Phase Phase III
ClinicalTrials.gov NCT01940341
Treatments
Tenofovir alafenamide
, Tenofovir alafenamide
Tradename:VemlidyOther Names:TAF, Tenofovir AFClass:Oral Antivirals (Nucleos(t)ide Analogues)Tenofovir DF
Tenofovir DF
Tradename:VireadOther Names:TDF, tenofovir disoproxil fumarateClass:Oral Antivirals (Nucleos(t)ide Analogues)Funding
IndustryGilead Sciences
References
- Buti M, Gane E, Seto WK, et al. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet Gastroenterol Hepatol. 2016;1:196-206.
- Cathcart AL, Chan HL, Bhardwaj N, et al. No Resistance to Tenofovir Alafenamide Detected through 96 Weeks of Treatment in Patients with Chronic Hepatitis B Infection. Antimicrob Agents Chemother. 2018;62(10).pii: e01064-18
Official Title Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate for Treatment of Hepatitis B e Antigen-Positive Hepatitis B
Phase Phase III
ClinicalTrials.gov NCT01940471
Treatments
Tenofovir alafenamide
, Tenofovir alafenamide
Tradename:VemlidyOther Names:TAF, Tenofovir AFClass:Oral Antivirals (Nucleos(t)ide Analogues)Tenofovir DF
Tenofovir DF
Tradename:VireadOther Names:TDF, tenofovir disoproxil fumarateClass:Oral Antivirals (Nucleos(t)ide Analogues)Funding
IndustryGilead Sciences
References
- Chan HL, Fung S, Seto WK, et al. Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet Gastroenterol Hepatol. 2016;1:185-95.
Common TitleFINITE Industry
Official Title FINITE CHB - First Investigation in Stopping Tenofovir Disoproxil Fumarate (TDF) Treatment After Long Term Virologic Suppression in HBeAg-negative Chronic Hepatitis B
Phase Phase IV
ClinicalTrials.gov NCT01320943
Treatments
Tenofovir DF
Tenofovir DF
Tradename:VireadOther Names:TDF, tenofovir disoproxil fumarateClass:Oral Antivirals (Nucleos(t)ide Analogues)Funding
IndustryGilead Sciences
References
- Berg T, Simon KG, Mauss S, et al. Long-term response after stopping tenofovir disoproxil fumarate in non-cirrhotic HBeAg-negative patients - FINITE study. J Hepatol. 2017;67:918-924.
Tenofovir DF Slide Deck
March 1, 2020
Clinical Trial Image Decks
Study 102 (GS-US-174-0102) - March 1, 2020
Study 103 (GS-US-174-0103) - March 1, 2020
Study 108 (GS-320-0108) - March 1, 2020
Study 110 (GS-320-0110) - March 1, 2020