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Self-Study HBV Lessons
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Self-Study HBV Lessons

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Core Competencies

HBV Epidemiology

Topic
Learning Objectives
Background
HBV Incidence in the United States
HBV Prevalence in the United States
Awareness of HBV Infection Status
Global HBV Epidemiology
Risks Associated with HBV Acquisition
CDC Case Definition and Reporting
HBV Disease Burden
Summary Points

HBV Screening, Testing, and Diagnosis

Topic
Learning Objectives
HBV Screening Recommendations
HBV Tests
Recommended Screening Tests
Incorporation of HBV Screening into Clinical Workflows
Evolution of Serologic Tests after Infection and Vaccination
Interpretation of HBV Serologic Tests
Summary Points

HBV Immunizations

Topic
Learning Objectives
Background
Vaccine Uptake
Indications for Hepatitis B Vaccination
Prevaccination Serologic Testing
HBV Vaccines and Schedules
Response to HBV Vaccines
Postvaccination Serologic Testing
Management of HBV Vaccine Nonresponders
Summary Points

Initial Evaluation of Persons with Chronic Hepatitis B

Topic
Learning Objectives
General Approach to the Initial Evaluation
Key Aspects of Medical History
Key Aspects of the Physical Examination
Initial Laboratory Evaluation
Screening for Other Causes of Liver Disease
Evaluation of Fibrosis Stage
Immunizations for Persons with Chronic HBV and Cirrhosis
Counseling Persons with Chronic HBV Following Diagnosis
Summary Points

When to Initiate HBV Treatment

Topic
Learning Objectives
Background
Goals of Therapy with Treatment of Chronic HBV
Factors Used to Determine Whether to Initiate Treatment
Hepatitis B Treatment Guidance Recommendations
Special Indications for Initiating Treatment
Summary Points

Choosing an Initial HBV Treatment Regimen

Topic
Learning Objectives
Background
Oral Antiviral Therapy Options for HBV
Peginterferon-Based Therapy for HBV
Choosing Oral Antivirals versus Peginterferon
Recommendations for Initial HBV Therapy
Summary Points

Monitoring Persons On and Off HBV Therapy

Topic
Learning Objectives
Introduction
Monitoring Persons with Chronic HBV Who are Not on Treatment
Safety Monitoring in Persons with Chronic HBV on Treatment
Definitions Used for Monitoring Response to Therapy
Monitoring Treatment Response in Persons with Chronic HBV
Overview of Monitoring Persons on Hepatitis B Treatment
Discontinuation of Antiviral Therapy Based on Treatment Response
Monitoring after Antiviral Therapy is Stopped
Summary

Preventing HBV Perinatal Transmission

Topic
Learning Objectives
Universal Screening for HBV Infection During Pregnancy
Risk of Perinatal HBV Transmission
Route and Timing of Perinatal HBV Transmission
Management of Women with Chronic HBV in Pregnancy
Management of Acute HBV in Pregnancy
Safety of Antivirals During Pregnancy
Hepatitis B Flares During Pregnancy and in the Postpartum Period
Management of Neonates Born to HBsAg-Positive Mothers
Breastfeeding in HBsAg-Positive Mothers
Summary Points

Screening for Hepatocellular Carcinoma

Topic
Learning Objectives
Epidemiology of HBV-Associated Hepatocellular Carcinoma (HCC)
Factors that Impact HBV-Associated HCC
Prognosis of Persons Diagnosed with HCC
Benefit of HCC Screening in Persons with HBV
HCC Surveillance Testing Methods
AASLD Guidance for HCC Surveillance
Summary Points

Occupational HBV Postexposure Prophylaxis

Topic
Learning Objectives
Background
Risk of HBV with Occupational Exposures
Initial Approach to Postexposure Prophylaxis
Interventions for HBV Occupational Postexposure Prophylaxis
Management of Occupational Exposure to HBV
Monitoring of HCP after Occupational HBV Exposure
Efficacy of Occupational Postexposure Prophylaxis for HBV
Summary Points

Hepatitis B Reactivation in the Setting of Immunosuppression

Topic
Learning Objectives
Background and Definitions
Pathophysiology of HBV Reactivation
Clinical Features of HBV Reactivation
Risk Factors for HBV Reactivation
Assessing Risk for HBV Reactivation
Risk Categories for HBV Reactivation
HBV Screening Prior to Initiation of Immunosuppression
Data on Antiviral Therapy to Prevent HBV Reactivation
Professional Society Recommendations for HBV Prophylactic Antiviral Therapy
Special Populations to Consider for HBV Reactivation
Summary Points

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